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The Feature Paper can be either an original research article, a substantial novel research study that often involves several techniques or approaches, or a comprehensive review paper with concise and precise updates on the latest progress in the field that systematically reviews the most exciting advances in scientific literature. This type of paper provides an outlook on future directions of research or possible applications.
This file contains the raw output data from OligoWalk and in-house script for portioning 18-mer ScanFold data for all six genes of interest.
This file contains a single folder for each gene studied. These folders contain the raw ScanFold-Scan output data such as per nucleotide MFE, ED, z-score, input, and output fasta files, and out file.
This file contains a single folder for each gene studied. These folders contain the raw ScanFold-Fold output data such as the log file, base pair track, final partners data, all dot bracket files, all CT files, extracted structures gff3 file, and the global VARNA 2D model.
With a greenfield approach, it’s important to assess the organization’s experience with a particular geographic location in terms of technical knowhow and understanding of the talent and customer segments. Additionally, there may be several methods to “go greenfield,” such as setting up your own facility, licensing it, or forging a new joint venture. However, locating, designing, and building a new smart factory from the ground up is challenging for even well-established companies. This approach generally requires significant capital outlays and construction timelines compared to other approaches. Real estate cost, tax implications, workforce recruiting and retention, and supply chain partners are important to address before building a new smart factory.
Greenfield operations provide the potential to reimagine your business; however, moving forward without a honed and disciplined plan could be disastrous. It’s important to take all factors into consideration, simulate, and test using digital twins to ensure accurate construction and delivery. Before you bend metal or pour concrete, you should know exactly the capacity, capability, and cost of the expected facility by having an exact virtual replica (a digital twin), which permits comprehensive modeling, simulation, testing, and evaluation of the proposed factory. Additionally, this digitalization can be invaluable to help ensure detailed oversight of the product, production, and performance of your new facility for years to come.
Since there are many moving parts to a reshoring and localization discussion, creating a scorecard or checklist to closely examine factors and associated favorability scores helps compare options (figure 1). However, despite thorough planning, there will be uncertainties associated with changes in climate, political environments, and other factors that could impact the outcome of a decision in either direction.
VMs, however, can take up a lot of system resources. Each VM runs not just a full copy of an OS, but a virtual copy of all the hardware that the operating system needs to run. It’s why VMs are sometimes associated with the term “monolithic”—they’re single, all-in-one units commonly used to run applications built as single, large files. (The nickname, “monolithic,” will make a bit more sense after you learn more about containers below.) This quickly adds up to a lot of RAM and CPU cycles. They’re still economical compared to running separate actual computers, but for some use cases, particularly applications, it can be overkill, which led to the development of containers.
